Very low density lipoprotein metabolism in non-ketotic diabetes mellitus: Effect of dietary restriction

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Abstract
We have measured the turnover of very low density lipoprotein (VLDL) triglyceride as well as plasma glucose, insulin and non-esterified fatty acid levels in nine mildly obese non-ketotic, insulinopenic diabetic subjects before and during an energy restricted diet. During the baseline period, subjects were hypertriglyceridaemic, hyperglycaemic and insulinopenic. During dietary restriction (mean weight loss: 2.3±0.4 kg) plasma triglyceride fell from 8.4±3.0 to 3.4±0.89 mmol/l (mean±SEM; ppp<0.05 versus baseline) while the fractional catabolic rate remained constant at 0.21±0.06/h (NS versus baseline). These data indicate that the major abnormality in triglyceride metabolism in these non-ketotic, insulinopenic diabetic patients was over-production of VLDL-triglyceride.

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