Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development.

  • 1 June 2001
    • journal article
    • review article
    • Vol. 3  (3) , 239-43
Abstract
Locked nucleic acids (LNAs) are a family of conformationally locked oligonucleotide analogs inducing unprecedented binding affinity towards DNA/RNA target sequences. Importantly, by virtue of the structural resemblance of LNAs to natural nucleic acid monomers, a combination of LNA chemistry with other oligonucleotide chemistries can be exploited to fine-tune the properties towards optimized antisense drug development and target validation technology. The first promising antisense results from experiments with LNA in living animals are described.

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