Comparison of hexachlorophane and chlorhexidine powders in prevention of neonatal infection.

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Abstract
The protective effect of treating the skin of newborn infants with powders containing 1% chlorhexidine or 0.33% hexachlorophane was compared. Each was equally effective in preventing colonization and infection by Staphylococcus aureus. In contrast, the skin became profusely colonized by coagulase-negative staphylococci, irrespective of the poweder used. Venous blood concentrations of chlorhexidine were low or undetectable in the few infants whose blood was analyzed.