Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
Open Access
- 8 February 2008
- journal article
- Published by Springer Nature in Molecular Neurodegeneration
- Vol. 3 (1) , 3
- https://doi.org/10.1186/1750-1326-3-3
Abstract
Parkinson's disease (PD) is the most prevalent incurable neurodegenerative movement disorder. Mutations in LRRK2 are associated with both autosomal dominant familial and sporadic forms of PD. LRRK2 encodes a large putative serine/threonine kinase with GTPase activity. Increased LRRK2 kinase activity plays a critical role in pathogenic LRRK2 mutant-induced neurodegeneration in vitro. Little is known about the physiological function of LRRK2.Keywords
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