SKIN STRETCHING AND EPIDERMOPOIESIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 58  (1) , 35-39
Abstract
In order to determine whether the heightened epidermopoiesis seen over dermal expansile lesions is due to stretch, attempts were made to induce similar degrees of skin stretching by implanting Silastic materials in the dermis of guinea-pigs. Silastic elastomer produced mild inflammation and so this model could not be used to evaluate the effects of stretch alone. Silastic testicular implants caused no inflammation and initially stimulated a rise in thymidine autoradiographic labeling index, but no increase in epidermal thickness during the experiment. There apparently is an increase in the germinative pool size caused by stretch but the epidermal hyperplasia seen over dermal lesions is probably due to some other process.

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