Chromosome banding, isoenzyme studies and determination of epstein-barr virus DNA content on human burkitt lymphoma/mouse hybrids

15 December 1977

journal article
research article
Published by Wiley in International Journal of Cancer

Vol. 20 (6) , 849-853
https://doi.org/10.1002/ijc.2910200605

Abstract

Four independently fused hybrid clones derived from a cross between the mouse mammary carcinoma TA3Ha and the human Burkitt lymphoma line Daudi were tested for the EBV‐determined nuclear antigen (EBNA), EBV‐DNA and the presence of human chromosomes, in the course of serial propagation in vitro. EBNA and EBV‐DNA were lost in parallel with the loss of human chromosomes. It seems that the persistence of EB‐viral genetic information does not require the presence of a specific human chromosome(s) in this particular hybrid combination.

Keywords

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