Dopamine Uptake Sites and Dopamine Receptors in Parkinson’s Disease and Schizophrenia
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 30 (1) , 9-14
- https://doi.org/10.1159/000117168
Abstract
Dopamine uptake sites, labelled by 3 nM [3H]GBR 12935, were reduced by 28–34% in post-mortem Parkinson’s diseased striata (n = 22) compared to control striata (n = 28). There was no significant difference between post-mortem striata from schizophrenics (n = 16) and controls. Both dopamine D1 and D2 receptors are consistently elevated in Parkinson’s diseased striata from patients who have not been medicated with L-dopa pre-mortem. Both these receptors are down-regulated by L-dopa pre-mortem. In schizophrenia, however, while the density of D1 receptors is similar to control, the D2 receptors are consistently elevated.Keywords
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