Randomized, comparative study of oral cefadroxil and cephalexin in lower respiratory infections in adults

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Abstract
In a multicentre, randomized study, 113 adults with lower respiratory tract infections with positive bacterial cultures, clinical evidence of pneumonia and abnormal chest X-rays were treated comparing oral cefadroxil to oral cephalexin. There were 60 adults treated with 500–1000 mg of cefadroxil twice daily and 53 treated with 250–500 mg of cephalexin four times a day. There were two treatment failures in each group. In 54 subjects with acute bacterial pneumonia due to Streptococcus pneumoniae, 30 subjects (20 cefadroxil: 10 cephalexin) had positive sputum cultures, clinical evidence of pneumonia, and abnormal X-rays. An additional 24 subjects (16 cefadroxil–8 cephalexin) had pneumococci in the Gram-stain of sputum but negative cultures and positive clinical and X-ray evidence of pneumonia. The cefadroxil subjects were treated with 500 mg twice daily and the cephalexin subjects with 250 mg four times daily. There was no difference demonstrated in the effectiveness of treatment in either group. There was one treatment failure in each group.

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