The case for a US prospective cohort study of genes and environment

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Abstract
Information from the Human Genome Project will be vital for defining the genetic and environmental factors that contribute to health and disease. Well-designed case–control studies of people with and without a particular disease are essential for this, but rigorous and unbiased conclusions about the causes of diseases and their population-wide impact will require a representative population to be monitored over time (a prospective cohort study). The time is right for the United States to consider such a project.