Effect of pH on the induction of competence and progression to the S‐phase in mouse fibroblasts
- 20 January 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 195 (1-2) , 309-312
- https://doi.org/10.1016/0014-5793(86)80183-1
Abstract
The pH dependence of competence induction and progression to the S‐phase in quiescent stimulated cells has been studied. The results show that: (i) induction of competence by fibroblast growth factor in these cells is relatively independent of the external pH between pH 5.6–7.6; (ii) progression of cells to the S‐phase is highly sensitive to pH and shows a dramatic increase between pH 6.8–7.2. These observations suggest that the intracellular alkalinization triggered by growth factors is fundamental for progression but not for competence induction.Keywords
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