TRANSLOCATED C-MYC GENES PRODUCE CHIMERIC TRANSCRIPTS CONTAINING ANTISENSE SEQUENCES OF THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS IN MOUSE PLASMACYTOMAS

1 May 1988

journal article
research article

Vol. 2 (5) , 469-476

Abstract

Immunoglobulin heavy chain gene antisense transcripts contribute to the expression of translocated c-myc genes in several murine plasma cell tumors. These novel, chimeric transcripts comprise 5-50% of steady-state c-myc mRNA. Two transcripts isolated as cDNA clones use the normal splice donor and acceptor sites within the c-myc first intron. Another cDNA clone has the potential for encoding two types of c-myc proteins. The significance of immunoglobulin heavy chain gene antisense transcripts and transcriptional competence of the immunoglobulin heavy chain locus for c-myc expression is discussed.

This publication has 1 reference indexed in Scilit:

Proteins encoded by v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines
Cell, 1983