Cerebral Edema following Acute Hemorrhage in a Murine Model

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Abstract
Unanesthetized male Sprague-Dawley rats were bled 40% of their blood volume. After 1 h of hypovolemia, the animals were resuscitated with either lactated Ringer''s solution (LRS) or hypertonic lactated saline (HLS). They received a volume of crystalloid equal to the shed blood volume or twice the shed blood volume. At 24 h after resuscitation, the animals were sacrificed and the brains excised. The percent water content was determined. Severe hemorrhage without resuscitation resulted in significantly increased intracerebral water content (77.7 .+-. 1.0 vs. 78.9 .+-. 0.7; P < 0.05). Resuscitation with twice the shed blood volume of either LRS or HLS prevented this inrease in intracerebral water. Adequate resuscitation is apparently the critical factor in preventing cerebral edema following acute severe hemorrhage.

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