Temperature dependence of phalloidin response in isolated rat hepatocytes
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 300 (2) , 193-194
- https://doi.org/10.1007/bf00505051
Abstract
Below 21° C isolated hepatocytes are insensitive to phalloidin. Between 21 and 30° C the amount of affected cells increases to nearly maximal values, whereas a further rise of the temperature has little additional effect. These findings suggest that phase transition of membranal lipids might be responsible for the unusual temperature characteristics. The fluidity of lipids seems to control an early step of the phalloidin response.Keywords
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