Quantitative Studies on the Inherited Variants of Serum α1-antitrypsin
- 1 January 1969
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 23 (1) , 97-103
- https://doi.org/10.3109/00365516909078092
Abstract
Each Pi allele, determining a genetic variant of α1-antitrypsin, results in eight protein zones when human serum is subjected to electrophoresis in starch gels, pH 4.9. Antigen-antibody crossed electrophoresis was adapted to the immunological quantitation of proteins separated by starch gel electrophoresis. The distribution of α1-antitrypsin among the Pi zones is different from the normal in the allele products of Pi1 and Pi2. The concentration of this protein is lower than normal in the serum from subjects of phenotype SS, MS, ZZ and MZ.Keywords
This publication has 7 references indexed in Scilit:
- SERUM Pi TYPES IN SOME EUROPEAN, AMERICAN, ASIAN AND AFRICAN POPULATIONSActa Pathologica Microbiologica Scandinavica, 1968
- SERUM Pi TYPES IN NORWEGIANSActa Pathologica Microbiologica Scandinavica, 1967
- The polymorphism of “prealbumins” and α1-antitrypsin in human seraClinica Chimica Acta; International Journal of Clinical Chemistry, 1967
- Obstructive Lung Disease and Trypsin Inhibitors in α1-Antitrypsin DeficiencyScandinavian Journal of Clinical and Laboratory Investigation, 1967
- Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodiesAnalytical Biochemistry, 1966
- A Multiple Comparison Procedure for Comparing Several Treatments with a ControlJournal of the American Statistical Association, 1955
- Une micro-méthode de l’immuno-électrophorèseInternational Archives of Allergy and Immunology, 1955