Sphingomyelinase Induces Aggregation and Fusion of Small Very Low–Density Lipoprotein and Intermediate-Density Lipoprotein Particles and Increases Their Retention to Human Arterial Proteoglycans
- 1 August 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 25 (8) , 1678-1683
- https://doi.org/10.1161/01.atv.0000168912.42941.60
Abstract
Objectives— Infiltration of low-density lipoprotein (LDL) into subendothelial space is an early step in atherosclerosis. In addition to LDL particles, small very low–density lipoprotein (sVLDL) and... Lipolysis of small VLDL and IDL particles by sphingomyelinase induces their aggregation and fusion and enhances binding of the particles to proteoglycans. The results suggest that sphingomyelinase-...Keywords
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