Rabbit Autoantibodies to Aorta

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Abstract
Antisera of rabbits immunized with antigenic preparations of bovine and human aortic intima reacted also with extracts of rabbit aorta, and two antigens characteristic of this tissue could be detected by these antisera. Two analogous antigens could also be identified by using the antisera of rabbits immunized with pooled rabbit aorta preparations in Freund's adjuvant. One of these antigens was a thermolabile component with fast electrophoretic mobility, presumably a protein; the other was a thermostable ethanol-insoluble component closely related to previously described tissue-specific BE antigens. Reactions with antigenic preparations derived from the antibody-producing animal provided evidence for the autoantibody nature of the antibodies under investigation.

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