Increased salivary interleukin-6 levels in patients with primary Sjögren's syndrome
- 24 March 1999
- journal article
- clinical trial
- Published by Springer Nature in Rheumatology International
- Vol. 18 (4) , 125-127
- https://doi.org/10.1007/s002960050070
Abstract
This study's purpose was to evaluate salivary interleukin-6 (IL-6) levels in patients with primary Sjögren's syndrome (SS). Salivary and serum IL-6 concentrations were evaluated by ELISA in 36 patients with SS and compared with 19 patients complaining of dry mouth and with normal controls. Salivary IL-6 levels were significantly elevated (Pr = 0.8613, P<0.0001) was found between salivary IL-6 levels and the focus score of labial biopsies in SS patients. Elevated salivary IL-6 levels appear to be a consequence of local production and may reflect the component of salivary gland inflammation in SS.Keywords
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