A Novel Stereocontrolled Synthesis of 3-(1′-Hydroxyethyl)-2-Azetidinone
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (03) , 239-240
- https://doi.org/10.1055/s-1993-22418
Abstract
A stereoselective synthesis of 3-(1′-hydroxyethyl)-2-azetidinone, a key synthetic intermediate of carbapenem, is described.The method is based on a strategy that involves the selective imine-aldol reaction of a chiral imine with a silyl ketene acetal in the presence of a chiral boron reagent.Keywords
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