Immunogenicity of Whole Cell and Outer Envelope Leptospiral Vaccines in Hamsters

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Abstract
The immunogenicity of leptospiral whole cell (WC) and outer envelope (OE) vaccines from virulent and avirulent strains was compared in hamsters. The 50% protective dose against death (PD 50D ) and kidney infection (PD 50K ) was evaluated for serotypes icterohaemorrhagiae, canicola, pomona , and grippotyphosa. The OE and WC of virulent strains possessed greater immunogenicity than the OE and WC of avirulent strains. More vaccine (50K than for the PD 50D (hardjo were combined to form a pentavalent OE vaccine which proved to be satisfactory in immunogenic potency. Duration of immunity was not evaluated.