Cells from normal brain and gliomas synthesize pregnancy-specific β1-glycoprotein-like material in vitro

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Abstract
The synthesis of pregnancy-specific .beta.1-glycoprotein (SP1) was studied in normal [human] brain-derived and malignant glial-cell cultures. The normal brain-derived and glioma cells contained SP1 when studied by radioimmunoassay and by the triple-bridge immunoperoxidase technique. The active synthesis of SP1 by these brain-derived cells was confirmed by metabolic labeling and subsequent immune precipitation of the culture medium. The SP1-like material produced by the brain-derived cells had the same MW as purified placental SP1.