Mucosal exudation of plasma is a noninjurious intestinal defense mechanism
- 1 November 1993
- Vol. 48 (8) , 581-586
- https://doi.org/10.1111/j.1398-9995.1993.tb00752.x
Abstract
We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestineKeywords
This publication has 14 references indexed in Scilit:
- The use of the nose to study the inflammatory response of the respiratory tract.Thorax, 1992
- Allergen-Induced Mucosal Exudation of Plasma into Rat Ileum and Its Inhibition by BudesonideScandinavian Journal of Gastroenterology, 1992
- Allergen, bradykinin, and capsaicin increase outward but not inward macromolecular permeability of guinea‐pig tracheobronchial mucosaClinical and Experimental Allergy, 1991
- Asymmetrical effects of increases in hydrostatic pressure on macromolecular movement across the airway mucosa. A study in guinea‐pig tracheal tube preparationsClinical and Experimental Allergy, 1991
- Plasma exudation as a first line respiratory mucosal defenceClinical and Experimental Allergy, 1991
- Divalent hapten-induced intestinal anaphylaxis in the mouse enhances macromolecular uptake from the stomachGastroenterology, 1990
- Subepithelial Hydrostatic Pressure May Regulate Plasma Exudation across the MucosaInternational Archives of Allergy and Immunology, 1990
- Antigen-Induced Mucosal Damage and Restitution in the Small Intestine of the Immunized RatInternational Archives of Allergy and Immunology, 1990
- ROLE OF PLASMA EXUDATION IN ASTHMATIC AIRWAYSThe Lancet, 1986
- Effect of locally induced intestinal anaphylaxis on the uptake of a bystander antigenJournal of Allergy and Clinical Immunology, 1981