CARCINOGENICITY OF CHRYSAZIN IN LARGE-INTESTINE AND LIVER OF MICE
- 1 September 1986
- journal article
- research article
- Vol. 77 (9) , 871-876
Abstract
The carcinogenicity of chrysazin (1,8-dihydroxy-9,10-anthracenedione) was examined by dietary administration to C3H/HeN mice. All of the effective mice (17) which were given 0.2% chrysazin diet and which survived more than 500 days developed adenomatous hyperplasia with cystic glands of the cecum. Similar lesions were also seen in the colon of mice in this group. These intestinal lesions were not obtained in any effective mouse (19) of the control group. The incidence of hepatocellular carcinoma of mice given chrysazin (4/17) was significantly higher than that of the controls (0/19). These results indicate that chrysazin is carcinogenic in mice as well as in rats. Some mechanistic aspects of the causation of these intestinal lesions and liver neoplasms are also discussed.This publication has 4 references indexed in Scilit:
- GENOTOXICITY OF A VARIETY OF MYCOTOXINS IN THE HEPATOCYTE PRIMARY CULTURE DNA-REPAIR TEST USING RAT AND MOUSE HEPATOCYTES1984
- Mutagenicity of anthraquinones in the Salmonella preincubation testMutation Research/Genetic Toxicology, 1983
- Mutagenicity of anthraquinone and benzanthrone derivatives in the salmonella/microsome test: Activation of anthraquinone glycosides by enzymic extracts of rat cecal bacteriaMutation Research/Genetic Toxicology, 1979
- Mutagenesis by 9,10-anthraquinone derivatives and related compounds in Salmonella typhimuriumMutation Research/Genetic Toxicology, 1976