Abstract
Sera from 150 individuals from southern Italy were screened for .alpha.1-antitrypsin (.alpha.1AT) types. The frequencies of the Pi alleles were compared with those found in northern Italy and central/southern Italy. The PiS frequency (0.02667) was lower than that found in central/southern Italy (0.0670) but matched with the result obtained in northern Italy (0.0297). The gene frequencies for subtypes of M in northern and southern Italy are presented.