Neurochemical Characterization of an Antimony‐Choline Analog in Rat Cortical Synaptosomes
- 1 August 1982
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 39 (2) , 321-326
- https://doi.org/10.1111/j.1471-4159.1982.tb03950.x
Abstract
An analog of choline, in which nitrogen was replaced by antimony, was neurochemically characterized in rat cortical synaptosomes. It was found to be a substrate for several cholinergic enzymes, transported by a Na+‐dependent, hemicholinium‐3‐sensitive process, acetylated, and subsequently released by depolarization in a calcium‐dependent manner. Sb‐choline also competed with choline for Na+‐dependent uptake and for acetylation by [14C]acetyl‐CoA in synaptosomes. These results suggest that Sb‐choline and its acetylated product should be useful substrates for the x‐ray microanalytical localization of cholinergic pools in intact nerve terminals.Keywords
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