The Modulating Effect of Estrogens on Luteinizing Hormone Release in complete Androgen Insensitivity Syndrome before and after Gonadectomy and Cyclic Steroid Application
- 1 August 1987
- journal article
- case report
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 90 (04) , 99-106
- https://doi.org/10.1055/s-0029-1210678
Abstract
The response of LH release to exogenous estrogens was studied in three patients with androgen insensitivity syndrome (AIS) before and after gonadectomy and a prolonged treatment with a sequential pill. Estrogen provocation tests were performed in which 0.05 mg/kg body weight estradiol benzoate was administered intramuscularly and serum FSH and LH levels were assessed every 12 hours for 96 hours after gonadectomy, three months after a prolonged treatment with a sequential pill (16 cycles: 9 days mestranol 100 μg, 12 days mestranol 80 μg and chlormadinone acetate 2 mg) and in one patient before gonadectomy. The control group consisted of 10 normal females during the follicular phase. A positive feedback effect was induced in normal females and in AIS patients after prolonged treatment with a sequential pill.Keywords
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