Emergence of New Antigens in Ageing Tissues

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Abstract
Ageing both in mice and the human is associated with the emergence of new antigenic determinant(s) which may be recognized by injecting the tissues into guinea pig and studying the sensitization developed by the animal’s lymphocytes, to normal and scrapie mouse brain or spleen. New antigenic determinant(s) appear in ageing tissues sufficiently like those found in scrapie mouse brain or spleen to give cross reactions with the latter. It is possible to use a preparation of lymphocytes or RBC as a ‘biopsy’ material to assess the position of an individual with respect to the emergence of the antigenic determinant(s) associated with ageing. The method might be used to study the influence of disease in general upon ageing in tissues.

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