ANGIOTENSIN-CONVERTING ENZYME IN MACROPHAGES AND FREUNDS ADJUVANT GRANULOMA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 14  (3) , 314-318
Abstract
Low angiotensin-converting enzyme (ACE) activity was found in rat and mouse peritoneal macrophages, in rat and rabbit pulmonary alveolar macrophages, in cultured and uncultured mouse peritoneal macrophages stiumulated i.p. for 4 days by thioglycollate and in rabbit pulmonary alveolar macrophages stimulated in culture by 0.1-100 .mu.g/ml Salmonella typhosa endotoxin for 4 days. Rat s.c. Freund''s adjuvant granulomas induced with Mycobacterium butyricum or M. tuberculosis H37 Ra contained low ACE activity which was generally lower than that present in control tissues. Increased ACE activity in sarcoidosis and Gaucher''s disease lesions does not reflect a universally high synthesis of ACE in mammalian macrophages or granulomas, but may be due to specific mechanisms.