Urinary Alpha-Ketolic Metabolites of Corticosterone and Cortisol Related to Body Size of Normal and Hypertensive Males

Publisher Website
Google Scholar
Abstract
The mean daily excretion of the tetrahydro alpha-ketolic metabolites of corticosterone and cortisol was determined for 40 male subjects from multiple measurements on urine collections representing 2–16 days. Paper chromatography was used for separation, and light transmission after reaction with blue tetrazolium was used for quantitation. The means and ranges in mg/day of the corticosterone metabolites were as follows: 15 normal men, .76 (.26–1.30); 13 men with essential hypertension, .84 (.40–1.40); 6 males with nonhypertensive, nonendocrine diseases, .80 (.54–1.04); 6 preadolescent boys, .43 (.20–.82). The means and ranges of the cortisol metabolites were: normal, 3.0 (1.1–5.8); hypertension, 3.7 (2.3–6.3); nonhypertensive male patients, 4.6 (2.0–6.9); boys, 1.1 (.38–2.70). The values for the 3 adult groups did not differ significantly. The log excretion values for all 4 groups combined exhibited a linear relationship to body surface area (r = 0.68 for corticosterone; 0.86 for cortisol). There was no change of excretion with age (up to the 6th decade) or mean blood pressure, other than that associated with change in body size.