A surface antigen influenza vaccine: 2. Pyrogenicity and antigenicity
- 1 August 1976
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 77 (2) , 173-180
- https://doi.org/10.1017/s0022172400024591
Abstract
Summary: Conventional influenza vaccine containing whole virus particles purified on a zonal centrifuge is pyrogenic and can cause systemic and local adverse side effects. An improved vaccine was therefore prepared which contained only the surface antigens of the virus adsorbed to aluminium hydroxide. The antigenicity of this vaccine was compared with conventional vaccine in chickens. Both vaccines induced similar titres of serum haemagglutination-inhibition and neuraminidase inhibition antibody. The dose response curves, however, were different. The surface antigens at vaccine strength without aluminium hydroxide were of negligible pyrogenicity in rabbits.This publication has 24 references indexed in Scilit:
- A surface antigen influenza vaccine. 1. Purification of haemagglutinin and neuraminidase proteinsEpidemiology and Infection, 1976
- An adsorbed surface-antigen influenza vaccine and its serological activity in volunteersPublished by Oxford University Press (OUP) ,1976
- A new surface-antigen-adsorbed influenza virus vaccine II. Studies in a volunteer groupEpidemiology and Infection, 1975
- A new, surface-antigen-adsorbed influenza virus vaccine. I. Studies on immunogenicity in hamstersEpidemiology and Infection, 1975
- Inactivated vaccines. 2. Laboratory indices of protectionPresented by the senior author before the symposium on Influenza Vaccines, London, 27 April 1972.Published by Oxford University Press (OUP) ,1973
- The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B virusesEpidemiology and Infection, 1972
- A Quantitative, Single-Radial-Diffusion Test for Immunological Studies with Influenza VirusJournal of General Virology, 1972
- A New Subunit Influenza Vaccine: Acceptability Compared with Standard Vaccines and Effect of Dose on AntigenicityThe Journal of Infectious Diseases, 1972
- Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccinesEpidemiology and Infection, 1971
- Enhancement and neutralization of pyrogenicity of influenza viruses by various biologically active substancesArchiv für die gesamte Virusforschung, 1969