Cardiac death and myocardial lesions in non-stroke SHRSP under specific pathogen-free system.

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Abstract
The most remarkable finding in SHRSP [stroke-prone spontaneously hypertensive rats] with cardiac death under specific pathogen-free system was idiopathic diffuse fatty degeneration of the myocardium. Besides fatty degeneration, diffuse myocardial fibrosis and scattered infarction were observed. In male rats the incidence of cardiac death increased with each generation. Therefore, this myocardial degeneration seemed to be a hereditary disorder. The SHRSP with cardiac death seemed to be a new type of SHR [spontaneously hypertensive rats], i.e., stroke-prone SHR (SHRHP). SHRHP may be a kind of animal model for congestive cardio9myopathy (COCM) in humans.

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