Viscosity and Stability Studies of Liquid Pafzaffin Emulsions Prepared by Hydroxypropyl Methylcellulose
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 19 (9) , 1083-1088
- https://doi.org/10.3109/03639049309063002
Abstract
Liquid paraffin-water emulsions were prepared by three viscosity grades of hydroxypropyl methylcellulose (HPMC) polymer which showed pseudoplastic behavior. The viscosity of emulsions increased, but the mean droplet diameter of globules decreased on increasing the concentration of the polymer. On storage at 25°C. the viscosity of emulsions stabilized by low viscosity grade polymers increased. For higher viscosity polymer, the emulsion viscosity initially increased and then decreased slightly on aging. Lower viscosity grade HPMC polymers have higher emulsifying efficiency. whereas higher viscosity grade polymer emulsion is much more stable towards centrifugation.Keywords
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