Differential patterns of acquired virulence genes distinguish Salmonella strains
- 14 April 1998
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 95 (8) , 4641-4645
- https://doi.org/10.1073/pnas.95.8.4641
Abstract
Analysis of several Salmonella typhimurium in vivo-induced genes located in regions of atypical base composition has uncovered acquired genetic elements that cumulatively engender pathogenicity. Many of these regions are associated with mobile elements, encode predicted adhesin and invasin-like functions, and are required for full virulence. Some of these regions distinguish broad host range from host-adapted Salmonella serovars and may contribute to inherent differences in host specificity, tissue tropism, and disease manifestation. Maintenance of this archipelago of acquired sequence by selection in specific hosts reveals a fossil record of the evolution of pathogenic species.Keywords
This publication has 28 references indexed in Scilit:
- The Complete Genome Sequence of Escherichia coli K-12Science, 1997
- Virulence regions and virulence factors of the ovine footrot pathogen,Dichelobacter nodosusFEMS Microbiology Letters, 1996
- Functional Relationships of the Genetic Locus Encoding the Glycosyltransferase Enzymes Involved in Expression of the Lacto-N-neotetraose Terminal Lipopolysaccharide Structure in Neisseria meningitidisPublished by Elsevier ,1996
- Molecular basis of intercellular adhesion in the biofilm‐forming Staphylococcus epidermidisMolecular Microbiology, 1996
- Cloning and sequence of a region encoding a surface polysaccharide of Vibrio cholerae O139 and characterization of the insertion site in the chromosome of Vibrio cholerae O1Molecular Microbiology, 1996
- Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesCell, 1995
- A family of clostridial and streptococcal ligand‐binding proteins with conserved C‐terminal repeat sequencesMolecular Microbiology, 1991
- A bacterial virulence determinant encoded by lysogenic coliphage λNature, 1990
- Cobalamin-dependent 1,2-propanediol utilization by Salmonella typhimuriumJournal of General Microbiology, 1990
- Nucleotide sequence, regulation and functional analysis of the papC gene required for cell surface localization of Pap pili of uropathogenic Escherichia coliMolecular Microbiology, 1987