The local effects of intra-arterial injections of sodium tetradecyl sulphate (s.t.d.) 3 per cent. An experimental study

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Abstract
The accidental intra-arterial injection of the commonly used sclerosant sodium tetradecyl sulphate (S.T.D.) 3 per cent during the treatment of varicose veins can affect seriously the blood-supply to the limb, and gangrene may follow. Intra-arterial injection of S.T.D. into the limb arteries of dogs chemically disintegrates the blood in the slow-moving stream of the capillaries and converts it into a thick sludge which obstructs the circulation locally, resulting in necrosis of the extremity.

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