Rat liver contains a potent endogenous inhibitor of inositol 1,3,4,5-tetrakisphosphate 3-phosphatase
- 1 May 1990
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 267 (3) , 831-834
- https://doi.org/10.1042/bj2670831
Abstract
When Ins(1,3,4,5)P4 was incubated with a rat liver 100000 g supernatant, about 93% of the substrate was metabolized by a 5-phosphatase, and only 7% by a 3-phosphatase. Ion-exchange chromatography of the supernatant specifically increased its 3-phosphatase activity 72 .+-. 3-fold. This activated enzyme was inhibited by a heat-stable factor present in both the soluble and particulate portions of the cell.This publication has 17 references indexed in Scilit:
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