Influence of Steroids on Carbohydrate Content of Rabbit Kidney: A Chromatographic Study.

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Abstract
Rabbits were treated with adrenal steroids (desoxycorti-costerone acetate, desoxycorticosterone acetate (DCA) plus cortisone, or prednisone) and the renal concentrations of the sugars rhamnose, mannose, fucose, glucose and galactose were determined by a semi-quantitative chromatographic method. Kidney tissue was also examined histologically. Rhamnose disappeared from the kidneys of the groups treated with DCA and cortisone or prednisone, and diminished in concentration in those receiving DCA alone. There was an increase in mannose and galactose content in all groups treated with steroids, but the levels of fucose and glucose were not significantly changed. These chemical alterations were discussed in relation to histologic changes involving the deposition of material staining positively by the periodic acid-Schiff method; the latter were observed in the groups treated with DCA and cortisone, or prednisone[long dash]but not in the group receiving DCA alone.