Variation in nucleolar organizer activity in lymphocytes of females with adenocarcinoma

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Abstract
With the use of Ag staining and conventional light microscopy, a difference is visualized in the frequency of nucleolar organizer regions [NOR] between PHA[phytohemagglutinin]-stimulated lymphocytest from normal females and females with various types of adenocarcinoma. This difference in NOR activity is more pronounced in G chromosomes than D chromosomes. r[ribosomal]DNA gene activity in PHA-stimulated lymphocytes evidently is augmented in patients with adenocarcinoma due to the presence of plasma mediators arising from cellular malignancies. The NOR regions located on G chromosomes are more sensitive to these mediators than those on D chromosomes.