The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair
- 1 October 2004
- journal article
- review article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 24 (4) , 664-673
- https://doi.org/10.1183/09031936.04.00096003
Abstract
Alveolar epithelial type I cells cover most of the internal surface area of the lungs.Ultrastructural studies demonstrate that alveolar epithelial type I cell damage is frequently observed in acute and chronic lung diseases.This article discusses the use of cell-selective proteins as markers for the investigation of injury and repair of the alveolar epithelium. The utility of proteins specific to alveolar epithelial type I cells as diagnostic markers of alveolar epithelial injury in acute lung injury is considered, and expression of proteins selective for alveolar epithelial type I cells in lungs following injury and in fibrosis are discussed.Keywords
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