Hemoglobin Legnano (α2141 (HC3) Arg → Leu β2): A New Abnormal Human Hemoglobin with High Oxygen Affinity

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Abstract
An abnormal, electrophoretically fast moving Hb was noted in a 34 yr old male patient living in Legnano (northern Italy) affected with renal failure and iron deficiency anemia, not related to the presence of the Hb variant. Structural studies demonstrated a previously undescribed amino acid substitution, .alpha. 141 Arg .fwdarw. Leu. This new variant was named Hb Legnano and was characterized by an increased oxygen affinity and a low cooperativity, at least as far as preliminary functional studies carried out on whole blood have indicated. Family studies are reported. Three other heterozygous carriers were observed among the relatives of the propositus, all showing a mild polycythemia which did not seem to produce appreciable clinical consequences.