Induction of ornithine decarboxylase by treatment of guinea pig lymphocytes with phospholipase C
- 24 January 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 151 (2) , 233-236
- https://doi.org/10.1016/0014-5793(83)80076-3
Abstract
Treatment of guinea pig lymphocytes with Clostridium perfringens phospholipase C but not with Naja naja snake venom phospholipase A2 increased ornithine decarboxylase activity. The increase in ornithine decarboxylase activity was suppressed by actinomycin D or cycloheximide, suggesting that de novo syntheses of RNA and protein are necessary for the increase in the enzyme activity. These results suggest that the activation of phospholipase C rather than that of phospholipase A2 is responsible for induction of ornithine decarboxylase during lymphocyte transformation.Keywords
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