Pediatric Primary Prevention of Atherosclerosis

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Abstract
In their careful assessment of the relation of lipids, lipoprotein cholesterols, and blood pressure in childhood to the development of aortic and coronary fatty streaks and fibrous plaques, Newman et al.1 strongly substantiate the concept that atherosclerosis begins in childhood and support pediatric approaches to the primary prevention of atherosclerotic coronary heart disease.1 2 3 The view that treatment of hypercholesterolemia in children will reduce adult morbidity and mortality from coronary heart disease is necessarily based on extrapolations from controlled clinical trials in middle-aged, high-risk, hypercholesterolemic men,4 5 6 since such studies have not been done in children. Dietary as well as cholestyramine-mediated lowering . . .