Quantitative Hemagglutination Inhibition Studies of Blood Group Substances

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Abstract
Summary: Comparative quantitative hemagglutination inhibition studies of the reactions of human anti-A with hog A substance have demonstrated differences in behavior of isoagglutinins in sera from individuals without known antigenic stimulus and those induced in normal subjects by either hog or human A substances. The naturally occurring isoagglutinins were characterized by a) hemagglutination inhibition log-probit assay curves of low slope, b) the requirement for larger doses of hog A to inhibit their hemagglutinating capacities, and c) possibly the ready dissociation of complexes formed with hog A substance. The isoagglutinins in nine antihog A sera were shown to be identical in nature whereas a marked variation was observed in the characters of anti-A isoagglutinins naturally occurring in the sera of 13 group B individuals.

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