The Concise Synthesis of a Key Intermediate for the Total Synthesis of Fumagillin, TNP-470, and Ovalicin
- 16 April 2008
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2008 (9) , 1460-1466
- https://doi.org/10.1055/s-2008-1067030
Abstract
The facile synthesis of a key intermediate for the total synthesis of the antiangiogenic compound fumagillin, its semisynthetic analogue TNP-470, and ovalicin is described. The methodology employs a Diels-Alder strategy and a zinc-mediated ring-opening reaction to realize the cyclohexane backbone.Keywords
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