COMPARATIVE ACTION OF STILBESTROL AND OTHER ESTROGENS ON ENDOMETRIUM OF THE CASTRATED GUINEA PIG11

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Abstract
53 castrated guinea pigs were injected thrice weekly with stilbestrol in the course of 3 mos., the dosage ranging between 0,1 and 1000 7 per inj. The conditions of the endometrium were studied and compared with those which were obtained with estradiol and estrone, and with 4 different esters of estradiol in more than 100 animals. A prolonged treatment with stilbestrol produced the same toxic actions as free or esterified natural hormones (uterine bleeding, cystic glandular hyperplasia, adenomatous polyps descending into the vagina, metaplasia with pluristratification etc.). The toxic dose of stilbestrol is, under equal timing conditions, smaller than that of the free natural hormones. The ratio between the "toxic uterine dose" and the "useful hysterotrophic dose" is with stilbestrol also smaller than with the natural free hormones. This means under the given exptl. conditions greater toxicity of stilbestrol. But stilbestrol is to its uterine toxicity somewhat more favourable than the esterified estradiol. This gives full corroboration to former findings with fibroids elicited by a prolonged treatment with different estrogens.

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