Immunoregulation of Malignant Lymphoma

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Abstract
In 1963 Oudin and Michel1 and Kunkel et al.2 independently reported that antibodies of a given specificity expressed serologically defined determinants of their own that distinguished them from other antibodies. These unique antigens on immunoglobulin molecules were designated idiotypes, and the antibodies that recognized them were designated anti-idiotypes.In 1974 Jerne3 proposed that antibody-producing cells were autoregulated by a network of idiotype-anti-idiotype interactions. A considerable body of experimental data4 supports Jerne's concept. Since the monoclonal immunoglobulin produced by each B-cell lymphoma, chronic lymphocytic leukemia, or myeloma expresses a unique idiotype, it is conceivable that patients with these neoplasms could benefit . . .