Effect of varying pH on the susceptibility ofCampylobacter pylori to antimicrobial agents

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Abstract
The susceptibility of 22 clinical isolates ofCampylobacter pylori to eight antimicrobial agents was studied under varying pH conditions. Macrolides (erythromycin, dirythromycin), clindamycin and to a lesser extent quinolones lost efficacy at lowered pH. The activity of ampicillin and metronidazole remained relatively stable throughout the pH range tested. The effect of pH an antimicrobial efficacy may warrant consideration when selecting an antibiotic to clearCampylobacter pylori in vivo, since the pH of the gastric submucous environment is not known for certain.