Relationship between Glycosylated Hemoglobin and the Prevalence of Proteinuria in Japanese Men.

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Abstract
A total of 5,174 Japanese men were included in a cross-sectional study to examine the relationship between the glycated hemoglobin (HbA(1C)) level and the prevalence of proteinuria as determined using a reagent strip. The prevalence of proteinuria rose significantly at HbA(1C) levels above 5.9%, whereas no relationship was observed at HbA(1C) levels below 5.9%, Multiple logistic regression analysis showed that blood pressure and a family history of diabetes were independent factors associated with proteinuria in subjects with a HbA(1C) below 5.9% who were not under medication for diabetes. In contrast, HbA(1C), obesity and smoking were associated with proteinuria in subjects who were under medication for diabetes and/or have a KbA(1C) above 5.9%, These findings suggest that maintaining a HbA(1C) level below 5.9%, non-smoking and a standard body weight may reduce the prevalence of proteinuria in Japanese men. Healthy life-style and standard body weight are especially important for subjects with a family history of diabetes.