Intranuclear inclusions of cytomegalic inclusion virus (CMV) were identified in 19 of 5,788 consecutive autopsies of cancer patients. The lungs were involved in 17 cases and the adrenal glands in seven. Steroid therapy had no influence on the presence of CMV in the adrenal glands. Concurrent Pneumocystis pneumonia was found in five patients. CMV was present in epithelial cells at the margins of six benign gastric or duodenal ulcers, an observation not previously emphasized. This might be an aggravating factor in steroid-induced ulcerative disease. Hypoalbuminemia and hypogammaglobulinemia appeared in the last 8 weeks of life of several patients, whereas leukopenia was usually present for many months before death. Some, but not all, patients with widespread or severe lesions due to CMV were deficient in serum albumin, gamma globulin, and peripheral leukocytes. Although most received whole blood transfusions at some time, fresh blood could not be implicated as a source of CMV in these patients.