CARBOXYL-LABELED C-11-1-AMINOCYCLOPENTANECARBOXYLIC ACID, A POTENTIAL AGENT FOR CANCER-DETECTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 17  (8) , 748-751
Abstract
Carboxy labeled 11C-1-aminocyclopentanecarboxylic acid (11C-ACPC) was prepared in multimillicurie amounts. The conversion of H11CN to 11C-ACPC (t1/2 = 20.4 min) was accomplished by a rapid (20-min) 2 step high temperature modification of the Buecherer-Strecker amino acid synthesis technique, which should be applicable at other accelerator installations. Purification was by ion exchange techniques. Animal studies indicated that 11C-ACPC is a potential tumor localizing agent for detecting cancer in humans by nuclear medicine scanning techniques.