Rate of Depletion and Route of Elimination of Intravenously Injected Gossypol in Swine

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Abstract
INJECTION of the sodium salt of free gossypol (15 mg/kg of body weight) via the jejunal vein resulted in serum total gossypol levels approximately 20 to 25% less than the average of similar jugular vein and carotid artery injections. Approximately 90% of the free gossypol injected was in the bound form 15 min. after injection, indicating that gossypol binds to serum proteins, serum iron or other substances. Livers from pigs that received gossypol via the jejunal vein contained 6% more gossypol than livers from pigs that received their gossypol by jugular and carotid injections. Elmination of injected gossypol (15 mg/kg of body weight) in the feces over a 93-hr, period accounted for 40% of the free gossypol injected. Fecal recovery was low for the first 24 hr., reached a peak at 48 hr. and then decreased rapidly. Total gossypol from the liver and spleen of these pigs was higher than found in the carotid, jugular and jejunal-treated pigs even though 40% of the gossypol had been eliminated apparently via the bile. Approximately 75% of the gossypol which was mixed with bile and placed in intestinal pouches was absorbed. No difference in the rate of absorption was found between the sodium salt of free gossypol and free gossypol dissolved in oil. Nearly twice as much gossypol was recovered from the bile fluid of pigs receiving the sodium salt of free gossypol (23%) as was recovered from pigs receiving free gossypol dissolved in oil (12%). Copyright © 1972. American Society of Animal Science. Copyright 1972 by American Society of Animal Science.

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