Cloned Mouse Mast Cells and Normal Mouse Peritoneal Mast Cells
- 1 January 1985
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 77 (1-2) , 189-191
- https://doi.org/10.1159/000233782
Abstract
We determined the serotonin (5-hydroxytryptamine, 5HT) content of growth factor dependent mouse mast cell lines or clones, and measured their ability to synthesize and store 3H-5HT from exogenous 5-hydroxy-[G-3H]-tryptophan (3H-5HTP) in vitro. Mast cells grown in vitro synthesized 3H-5HT from 3H-5HTP at rates equal to or greater than those of peritoneal mast cells freshly isolated from normal mice. Furthermore, under usual conditions of culture, mast cell lines or clones contained more 5HT than freshly isolated peritoneal mast cells.Keywords
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